The tournament was held for the first time at the Marshall Arena in Milton Keynes, England, between 5–7 March 2021, and was played behind closed doors due to the COVID-19 pandemic.

[1] Michael van Gerwen was the defending champion after defeating Gerwyn Price 11–9 in the 2020 final.

[3] James Wade won his third UK Open title, and his first since 2011, with an 11–5 victory over Luke Humphries in the final.

Boris Krčmar, Daniel Larsson, Darren Penhall, Wesley Harms, Michael Unterbuchner and Robert Marijanović withdrew before the draw was made.

[6] Justin Pipe tested positive for COVID-19, meaning Luke Humphries received a bye to round 4.