The 2021 Sioux Chief PowerPEX 200 presented by Scott County Tourism was the 19th stock car race of the 2021 ARCA Menards Series, the tenth and final race of the 2021 Sioux Chief Showdown, and the 25th iteration of the event.

[1] To fill out the podium, Rajah Caruth of Rev Racing would finish third.

Salem Speedway is a .555 miles (0.893 km) long paved oval motor racetrack in Washington Township, Washington County, near Salem, Indiana, approximately 100 miles (160 km) south of Indianapolis.

Major auto racing series that run at Salem are ARCA and USAC.

The only 45-minute practice session was held on Saturday, October 2, at 3:15 PM EST.