The 2021 Sprecher 150 was the 16th stock car race of the 2021 ARCA Menards Series season, the seventh race of the 2021 ARCA Menards Series East season, the eighth race of the 2021 Sioux Chief Showdown, and the sixth iteration of the event.

The race was held on Sunday, August 29, 2021, in West Allis, Wisconsin at the Milwaukee Mile, a 1 mile (1.6 km) permanent oval-shaped, low-banked racetrack.

The Milwaukee Mile is a one-mile-long (1.6 km) oval race track in the central United States, located on the grounds of the Wisconsin State Fair Park in West Allis, Wisconsin, a suburb west of Milwaukee.

In addition to the oval, there was a 1.8 mile (2.8 km) road circuit located on the infield.

As the oldest operating motor speedway in the world, the Milwaukee Mile has hosted at least one auto race every year from 1903 to 2015 (except during U.S. involvement in World War II).