2021 USL League Two Playoffs

It is the twenty-sixth edition of the Playoffs and the second under the USL League Two banner.

[1] There were no playoffs the previous season due to the COVID-19 pandemic.

[2] The Des Moines Menace won their third straight Regular Season Title (2018, 2019, 2021), with an average of 2.75 standings points per game.

The Menace defeated North Carolina Fusion U23 in the National Final 1–0 before a record crowd of 7,342.

Championship MVP: Manel Busquets (DMM)