The winners of the competition will qualify for the 2023–24 UEFA Europa League play-off round.
The lowest teams still in the competition were Cappellen, Lokeren-Temse and Meux, from the Belgian Division 2 (tier 4).
The draw took place on 10 November 2022 after the conclusion of the last game, which was Lierse Kempenzonen against Anderlecht.
The draw for the quarter-finals was made on Thursday 22 December, one day after the conclusion of the last match of the previous round.
All teams left played at the top level (Belgian Pro League).
[4] The draw for the semi-finals was made on Friday 13 January, one day after the conclusion of the last match of the previous round.