Egnatia won the cup, their first title in the competition.
Ties are played in a two-legged format similar to those of European competitions.
If the aggregate score is tied after both games, the match is decided by extra time and a penalty shoot-out, if necessary.
[1] In order to reduce the number of participating teams for the first round to 32, a preliminary tournament is played.
The matches were played on 25, 26, 28 September 2022 as well as 11 and 12 October 2022.
Dinamo Tirana advanced to the second round.
All eight qualified teams from the second round progressed to the quarter-finals.
Vllaznia advanced to the semi finals.
Teuta advanced to the semi finals.