The winner of the competition qualified for the play-off round of the 2023–24 UEFA Europa Conference League.

[2] Liverpool were the defending champions, having beaten Chelsea on penalties to secure a record 9th title in the previous season's final,[3] but were eliminated by Manchester City in the fourth round.

The draw for this round was split on a geographical basis into "northern" and "southern" sections.

The draw for this round was split on a geographical basis into "northern" and "southern" sections.

League Two side Gillingham was the lowest-ranked team in the draw, which was made on 10 November 2022.