On 14 May, Barcelona were confirmed as champions with four matches to spare following a 4–2 away victory against Espanyol, clinching the club's 27th league title and first since the 2018–19 season.
A total of twenty teams contested the league, including seventeen sides from the 2021–22 season and three promoted from the 2021–22 Segunda División.
The first team to be relegated from La Liga were Levante, after a 6–0 loss to Real Madrid on 12 May 2022, ending their five-year stay in the top tier.
The second team to be relegated was Alavés, after a defeat of 1–3 by Levante on 15 May 2022, ending their six-year stay in the top tier.
The first two teams to earn promotion from Segunda División were Almería and Real Valladolid, who mathematically secured first and second positions, respectively, on the very last match day of the season.