The 2021 Aragon motorcycle Grand Prix (officially known as the Gran Premio Tissot de Aragón) was the thirteenth round of the 2021 Grand Prix motorcycle racing season.

It was held at the MotorLand Aragón in Alcañiz on 12 September 2021.

In the Moto2 class, Red Bull KTM Ajo won their second Teams' Championship.

Below are the standings for the top five riders, constructors, and teams after the round.

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