The race weekend program underwent a change due to logistical difficulties affecting freight transport.

Five cargo flights were supposed to ship paddock material from Lombok, Indonesia, to Tucuman, near Termas de Rio Hondo in Argentina, in the week following the Indonesian GP.

Due to two separate issues affecting two different flights, the final cargo for the Argentine GP arrived in the country on Friday.

The first plane that had already arrived in Tucuman was then brought back to Lombok to collect more cargo, but this too suffered a technical problem during a layover the previous Wednesday evening.

Warm Up sessions on Sunday morning were extended, with each race set to begin at the same start time as originally scheduled.

Takaaki Nakagami was initially declared absent in this Grand Prix due to the positivity of the COVID-19 test and therefore unable to start.

[4] In Moto2 class, Barry Baltus was out for the weekend with a broken right wrist remedied during qualifying for the Indonesian Grand Prix.

[5] As already happened in the first two stages, Gerard Riu replaced David Muñoz because the latter was still under the limit minimum age to run in the category.

After the Indonesian Grand Prix, Enea Bastianini kept the lead of the riders' standings with 30 points, two more than Brad Binder and three more than Fabio Quartararo.

In the second session, Aleix Espargaró finished in the lead ahead of teammate Maverick Viñales and Jack Miller.