[5] On 14 July, despite having largely won the confidence vote, Prime Minister Draghi offered his resignation, which was rejected by President Sergio Mattarella.

[14][15] In January 2021, Matteo Renzi, leader of Italia Viva (IV), withdrew the support to Conte's cabinet, causing the fall of the government.

[16] During 2022, rumours arose around a possible withdrawal of M5S's support to the national unity government, and allegations were spread that Draghi had privately criticised Conte and asked M5S founder Beppe Grillo to replace him.

[31] After a few hours, Draghi resigned as prime minister; he claimed that, without the support of the M5S (who had received a plurality of votes in the previous general election), the democratic legitimacy of his Government was in jeopardy.

[32][33] In an official statement released by the presidential office, Mattarella called on Draghi to seek a debate and a vote in the Italian Parliament to better understand the positions of the several political parties before finalizing any decision.

[38] On 20 July, Draghi addressed the Senate, reiterating his support for the European Union, NATO, and Ukraine, and saying it was fully necessary to bring to term the economic and justice reforms his government started.

[47] In the morning of 21 July, Draghi offered again his resignation to President Mattarella, who had no choice but to accept it, since by then it had become clear the government lacked parliamentary support.