The 2022 Italian motorcycle Grand Prix (officially known as the Gran Premio d'Italia Oakley) was the eighth round of the 2022 Grand Prix motorcycle racing season and the third round of the 2022 MotoE World Cup.

The Grand Prix saw the retirement of Valentino Rossi's racing number 46 in the MotoGP class.

In Moto3, David Muñoz makes his debut this season in Boé SKX after he was replaced by Gerard Riu because he had not turned 16 years, the minimum limit to participate in the championship.

Alberto Surra returns to racing in the Rivacold Snipers Team after recovering from the injury due to the crash in the Grand Prix of the Americas.

After the French Grand Prix, Fabio Quartararo confirms his leadership in the drivers' standings with 102 points, 4 more than Aleix Espargaró and 8 more than Enea Bastianini (winner at Le Mans).

In the first session, Dominique Aegerter was the fastest, ahead of Eric Granado and Kevin Zannoni.