In the Moto2 class, after the termination of the contract between Speed Up and Romano Fenati, the team chose to replace him with Alonso López;[1] Stefano Manzi continues to replace Keminth Kubo in the Yamaha VR46 Master Camp Team, given the Thai rider's inadequacy.

[2] In the Moto3 class, in addition to the presence of Gerard Riu to replace David Muñoz on the KTM of the Boé SKX, the Italian rider Alberto Surra is still unavailable due to a fracture to his scaphoid in the GP of the Americas.

After being replaced in the stages of Portugal and Spain by the Malaysian Syarifuddin Azman, in this Grand Prix the choice of the Rivacold Snipers Team goes to the Spaniard José Antonio Rueda; while John McPhee returns to the track with the Sterilgarda Husqvarna Max team after he is healed in the vertebra.

In the MotoE class, Xavi Cardelús makes his debut this season in Avintia Esponsorama Racing after missing the opening stage in Jerez due to injury, while Bradley Smith is still out due to injury after his crash at the 24 Hours of Le Mans.

Izan Guevara, winner in Jerez, is third with 73 points, 3 more than Jaume Masià and 10 more than Deniz Öncü.

In the third session, Johann Zarco finished at the top of the standings ahead of Bagnaia and Fabio Quartararo.

Fabio Quartararo finished in the lead ahead of Álex Rins and Francesco Bagnaia.

In the first session, Mattia Casadei was the fastest, ahead of Jordi Torres and Miquel Pons.