Her 13-point margin of victory was the largest for a statewide Democratic candidate since George J. Mitchell won over 80% of the vote in the 1988 United States Senate election.

Mills's victory was also the largest for any gubernatorial candidate since incumbent Angus King won 59% of the vote in 1998.

[21] Access to abortion became a crucial issue following the Supreme Court's ruling in Dobbs v. Jackson Women's Health Organization, which overturned Roe v. Wade and eliminated the constitutional right to abortion, effectively returning the issue to the states.

[24] LePage would continue to struggle with questions on abortion, and a stumble in a debate with Mills on the topic led to national headlines.

[31] In the election, Mills broke her own record set four years earlier for most votes received by a Maine gubernatorial candidate.