The two statewide officer holders, Roy Blunt and Nicole Galloway, did not run for re-election leaving both statewide seats with no incumbents.

[2][3] Two of the seats for the House of Representatives were open as incumbent Vicky Hartzler and Billy Long both ran unsuccessfully for the open Senate seat.

Before the election, the composition of the Missouri State Legislature was: After the election, the composition of the Missouri State Legislature was: Senate District 2 Republican primary Senate District 10 Republican primary Senate District 12 Republican primary Senate District 16 Republican primary Senate District 20 Republican primary Senate District 22 Republican primary Senate District 24 General election Senate District 26 Republican primary There was four amendments as well as a question to rewrite the state constitution on the ballot in November.

[22][23] Amendment 1 changes how the State Treasurer of Missouri is allowed to invest taxpayer money.

[25] Amendment 4 makes an exception to the Hancock Amendment to allow the increase of required spending for the Kansas City Police put in place by SB 678.