Ernix Dionisio, Rolan Valeriano, Joel Chua, Edward Maceda, Irwin Tieng and Benny Abante were elected to be the representatives for the first, second, third, fourth, fifth and sixth districts respectively.

Moreno chose not to seek reelection as the mayor of Manila and will instead run for president of the Philippines in 2022.

[3] Lacuna's notable challengers for mayor are former Philippine National Police DICTM deputy director Elmer Jamias (People's Reform Party), former 5th district representative Amado Bagatsing (KABAKA), and Christy Lim-Raymundo (Reporma), the daughter of former mayor Alfredo Lim, who died in 2020.

Bagatsing also joined the mayoralty race during the substitution period; he previously ran for mayor in 2001 and in 2016 but lost.

[5] Meanwhile, in the vice mayoralty race, Nieto notably faced actor Raymond Bagatsing of Kilusang Bagong Lipunan.

Meanwhile, Lopez, another son of former Manila Mayor Mel Lopez and the current chair of the House Committee on Metro Manila Development, was chosen by the PDP–Laban–Cusi wing as its mayoral candidate[8] but chose to seek reelection for representative instead, with his brother Alex taking his place in the mayoralty race.

[1] Asenso Manileño, Moreno's party slated vice mayor Honey Lacuna to defend the position.

Asenso Manileño, Moreno's party slated 3rd District Representative Yul Servo to defend the position.

His party's nominee is incumbent city majority floor leader and Councilor Joel Chua.

His opponents are former Councilor and incumbent Barangay 299 Captain Ramon Morales and Clark Field Arroño III.

On October 6, 2022, the Commission on Elections dismissed the protest, citing the lack of evidence as well as the usage of baseless claims.