This was the third time that the Cleveland area hosted the All-Star Game, the first being in 1981 at the Coliseum in nearby Richfield, Ohio, and most recently in 1997—three years after the Cavaliers moved back to downtown Cleveland to play in the newly built Gund Arena, which is now known as Rocket Mortgage FieldHouse.

[1] The announcement of the site selection was made on November 1, 2018, at a press conference held by the Cleveland Cavaliers.

Trae Young of the Atlanta Hawks and DeMar DeRozan of the Chicago Bulls were named the backcourt starters in the East, earning their second and fifth all-star appearances, respectively.

Kevin Durant of the Brooklyn Nets and Giannis Antetokounmpo of the Milwaukee Bucks were named the frontcourt starters in the East, earning their 12th and sixth all-star appearances, respectively.

[12] Ja Morant of the Memphis Grizzlies and Stephen Curry of the Golden State Warriors were named to the starting backcourt in the West, earning their first and eighth all-star appearances, respectively.

In the frontcourt, Andrew Wiggins of the Golden State Warriors and LeBron James of the Los Angeles Lakers were named to their first and 18th all-star selections, respectively.

Joining them was reigning MVP Nikola Jokić of the Denver Nuggets, in his fourth all-star selection.

[15] ^INJ3 James Harden was unable to play due to a hamstring injury, but was present for the halftime ceremony.

LeBron James and Kevin Durant were named captains for the second straight year, as they both received the most votes from the West and East, respectively.

[21] The 2022 NBA All-Star Celebrity Game was played on Friday, February 18, 2022, at the Wolstein Center in Cleveland, Ohio.

A neutral site Mid-Eastern Athletic Conference (MEAC) college basketball game between the Howard Bison and Morgan State Bears was held on February 19, 2022, at the Wolstein Center as the inaugural NBA HBCU Classic.

Towns set the record for most points in the final round with 29 surpassing Devin Booker who had 28 in 2018, becoming the first center to win the event and the first Timberwolves player since Kevin Love in 2012.

[30] Toppin won his first NBA Slam Dunk Contest by defeating Juan Toscano-Anderson in the finals.

[37] Tyrese Haliburton of the Indiana Pacers and Desmond Bane of the Memphis Grizzlies were the winners of the 2022 Clorox Clutch Challenge, an event for the 75th season at the 2022 NBA All-Star Weekend.

[39] The runner-up teams consisted of Chris Duarte and Scottie Barnes, Evan Mobley and Josh Giddey, as well as G-League players Michael Foster Jr. and Fanbo Zeng.

[41] This is the first All-Star Game since 2000 (then aired on NBC) to not be called by Marv Albert, as he retired at the end of the 2020–21 NBA season.

)[42] Sister network TBS carried an alternate feed, Inside the All-Star Game, which featured a conversational presentation of the game featuring the Inside the NBA panel of Charles Barkley, Ernie Johnson, Shaquille O'Neal, and Kenny Smith, with guests such as Draymond Green.