[citation needed] In December 2012, Towns announced that he was going to reclassify as a senior and commit to play on the Kentucky Wildcats men's basketball team under Coach John Calipari.

[25] In the following game on October 30 against the Denver Nuggets, his 28 points and 14 rebounds propelled the Timberwolves to their first 2–0 start with two wins on the road in team history.

[28] On January 20, 2016, Towns had a season-best game with 27 points and career highs of 17 rebounds and six blocks in a 106–94 loss to the Dallas Mavericks.

[32][33] Three days later, he won the 2016 NBA All-Star Weekend Skills Challenge over point guard Isaiah Thomas, becoming the tallest, heaviest, and youngest winner of the event.

[37] Four days later, in a loss to the Houston Rockets, Towns passed Christian Laettner for the franchise's rookie scoring record with 1,475 points.

Towns had his 100th career double-double in the win, becoming the second-youngest player in league history to reach that mark, behind only Dwight Howard.

[49] On November 15, 2017, Towns had 26 points and 16 rebounds for Minnesota on the night he turned 22, helping the Timberwolves end a 12-game losing streak to the San Antonio Spurs with a 98–86 victory.

[50] Towns finished in the top 10 in almost every statistical category in NBA history compiled prior to the player's 22nd birthday.

[55] On March 28, 2018, he scored a franchise-record 56 points and added 15 rebounds for his league-leading 63rd double-double, as the Timberwolves beat the Atlanta Hawks 126–114.

[58] In the Timberwolves' regular season finale on April 11, 2018, Towns had 26 points and 14 rebounds in a 112–106 overtime win over the Denver Nuggets.

The win clinched Minnesota a spot in the playoffs for the first time since 2004—no team in the league had gone longer without a postseason appearance than the Timberwolves.

[59] In Game 3 of the Timberwolves' first-round playoff series against the Houston Rockets, Towns recorded 18 points and 16 rebounds in a 121–105 win.

[65] On December 5, Towns recorded 35 points, 12 rebounds and tied a career high with six blocks in a 121–104 win over the Charlotte Hornets.

[67] On January 30, he scored all 16 of his points after halftime, including a buzzer-beating desperation shot in overtime to lift the Timberwolves over the Memphis Grizzlies 99–97.

[68] Towns missed the first game of his career on February 22 against the New York Knicks after being placed in the concussion protocol following a car accident in Minnesota.

[69] The concussion protocol forced him to miss a second game,[70] with his return on February 25 seeing him record 34 points and 21 rebounds in a 112–105 win over the Kings.

[73] On October 23, 2019, in the first game of Minnesota's season, Towns scored 36 points, grabbed 14 rebounds, blocked 3 shots, and recorded 3 steals in a 127–126 win over the Brooklyn Nets.

[76] On December 27, 2020, Towns joined Hall-of-Famers Kareem Abdul-Jabbar, Tim Duncan, Elgin Baylor and David Robinson as the only players in NBA history to accumulate over 8,000 points, 4,000 rebounds and 1,000 assists in 360 games or less.

[84] On March 5, a 138–101 win over the Oklahoma City Thunder, Towns recorded 36 points, 15 rebounds, five assists, three blocks, and zero turnovers.

[87] On March 14, Towns recorded a then career-high and then Timberwolves franchise-record 60 points, 32 of which in the third quarter and grabbed 17 rebounds in a 149–139 win over the San Antonio Spurs.

[95] On April 9, in the final game of the 2022–23 season, Towns recorded 30 points and 8 rebounds to help lead the Timberwolves to a 113–108 win over the New Orleans Pelicans, earning the eight seed in the Western Conference play-in tournament.

[96] In the First Round, Timberwolves were eliminated from the playoffs by the eventual NBA champion Nuggets despite a 26-point and 11-rebound performance by Towns in the close-out Game 5 defeat.

[97] On November 18, 2023, Towns put up 29 points on 10-of-11 shooting from the field along with six rebounds, nine assists, two blocks, and a game-winning lay-up in a 121–120 win over the New Orleans Pelicans.

[99] On January 22, 2024, Towns put up a career-high and Timberwolves franchise-record 62 points, with 44 of those coming in the first half, in a 128–125 loss to the Charlotte Hornets.

[104] In game 4 of the first round of the playoffs, Towns scored 28 points and grabbed 10 rebounds in a 122–116 win over the Phoenix Suns to close out the series.

[105] In Game 7 of the Western Conference Semifinals, Towns recorded 23 points and 12 rebounds to help lead the Timberwolves to a 98–90 victory over the Denver Nuggets.

[109] On November 13, Towns scored a season-high 46 points on 60% shooting from the field and grabbed 10 rebounds in a 124–123 loss against the Chicago Bulls.

[110] On December 19, In his first game back at Target Center after a nine-year tenure with the Timberwolves, Towns recorded 32 points, 20 rebounds and six assists in a 133–107 victory.

With the performance, he joined Kareem Abdul-Jabbar (1975 vs. Milwaukee Bucks) as the only players to record 30+ points and 20+ boards in their first game back against their former team.

[114] He would not play for his national team in the following years, until he joined them for the 2023 FIBA Basketball World Cup, confirming his presence in July 2023.