The 2022 NCAA Division II football season, part of college football in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division II level, began on August 31 and ended on December 17 with the Division II championship at the McKinney Independent School District Stadium in McKinney, Texas.
Ferris State defeated Colorado Mines, 41–14, for its second consecutive championship.
September 10: Missouri S&T 17, Drake 14 OT September 17: Delta State 28, Mississippi Valley State 17 October 1: Lane 28, Tennessee State 27 OT The top 25 from the AFCA Coaches' Poll.
* - Host school Teams that advanced to the semifinals were re-seeded.
This list includes coaching changes announced during the season that did not take effect until the end of the season.