The wheelchair competitions were won by Marcel Hug of Switzerland and Susannah Scaroni of the United States, in course record times of 1:25:26 and 1:42:43 respectively.

[3] The 2022 New York City Marathon was sponsored by Indian company Tata Consultancy Services.

[14] Elkanah Kibet, the best finishing American at the 2021 event, withdrew after being called up by the US Army to serve abroad.

[16] Americans in the race included Aliphine Tuliamuk, who won the US trial event prior to the 2020 Summer Olympics, Sara Hall, Emma Bates[16] and Keira D'Amato.

[15] Peres Jepchirchir, who won the 2021 race, was originally scheduled to compete, but withdrew in October 2022.

[15] The men's wheelchair event featured 2021 winner Marcel Hug, as well as Daniel Romanchuk, who won the 2018 and 2019 races.

[17] The women's wheelchair race featured 2021 winner Madison de Rozario, who also won the marathon event at the 2022 Commonwealth Games.

Other competitors included five-time former winner Tatyana McFadden, three-time champion Manuela Schär and American Susannah Scaroni.

[20] The elite men's event was won by Kenyan Evans Chebet, in his first New York City Marathon.

[20] Brazilian Daniel do Nascimento led for much of the race, and at the halfway point, he had a lead of over two minutes on the chasing group.

[20] It was Hug's fifth New York City Marathon victory, tying him for most wins with Fearnley and Tatyana McFadden.

[26] Hug received $50,000 for breaking the course record,[21] and confirmed his World Marathon Majors title with the win.

[6] Sportspeople who raced included Norwegian cross-country skier Marit Bjørgen, Olympic ice hockey gold medalist Meghan Duggan, former tennis player Monica Puig, IndyCar driver Ryan Briscoe, former American footballer Tiki Barber, 800 meters runner Alysia Montaño and sportscaster Nicole Briscoe.

[28] Non-sporting celebrities who competed included actors Ashton Kutcher, Claire Holt, Lauren Ridloff,[28] Ellie Kemper and Sierra Boggess, Chelsea Clinton, the daughter of former US President Bill Clinton,[29] TV presenters Amy Robach and Nev Schulman, YouTuber Casey Neistat, television journalist Ana Cabrera, television personality Matt James and Oz Pearlman, who finished third in season 10 of America's Got Talent.