The 2022 Prefontaine Classic was the 47th edition of the annual outdoor track and field meeting in Eugene, Oregon, United States.

The meeting was initially highly anticipated due to announced world record attempts in the women's two miles and both the men's and women's 5000 metres.

[1] However, multiple high-level withdrawals caused concern, as Caster Semenya, Athing Mu, Matthew Centrowitz Jr., Rai Benjamin, and Sam Kendricks were all initially listed to compete but were not on the final start lists.

[2] Though no world records were set, the meeting was highlighted Jakob Ingebrigtsen winning the Bowerman Mile, and a women's 100 m showing improvement from both Elaine Thompson-Herah and Sha'Carri Richardson on the women's side.

[3][4] Athletes competing in the Diamond League disciplines earned extra compensation and points which went towards qualifying for the Diamond League finals in Zürich.