The 2022 Northern Illinois Huskies football team represented Northern Illinois University as a member of the West Division of the Mid-American Conference (MAC) during the 2022 NCAA Division I FBS football season.

The Huskies were led by fourth-year head coach Thomas Hammock and played home games at Huskie Stadium in DeKalb, Illinois.

[1] In the league's annual preseason poll, the Huskies were picked to win the West division.

[3] Offensive linemen Nolan Porter and Logan Zschernitz, wide receiver Trayvon Rudolph, cornerback Jordan Gandy, and kicker John Richardson were named to the preseason first team.

The Huskies played four non-conference games with visits to Tulsa and Kentucky and while hosting Eastern Illinois of the FCS and Vanderbilt at Huskie Stadium.