The season began on May 6, 2022, against the Las Vegas Aces[1] and ended in the 1st round of the WNBA Playoffs against the same team.
The season was marred by a number of issues, including injuries and the absence of Brittney Griner, who was detained in Russia on drug charges.
On December 6, 2021, the Mercury announced that they would not be renewing Sandy Brondello's contract and parted ways with her as Head coach.
[4] On August 11, 2022, the Mercury announced that Skylar Diggins-Smith would miss the final 3 games of the season for personal reasons.
[5] Despite injuries to two of their prominent players, the Mercury entered the final day of the season with a chance at qualifying for the playoffs.