In the intermediate class, the new entries are the 2021 Moto3 World Champion Pedro Acosta, Jeremy Alcoba, Gabriel Rodrigo, Niccolò Antonelli, Filip Salač (from Moto 3), Manuel González, Alessandro Zaccone, Keminth Kubo, Zonta van den Goorbergh and Sean Dylan Kelly.

There are eight new entries in the category: Diogo Moreira, Iván Ortolá, Joel Kelso, Daniel Holgado, Matteo Bertelle, Mario Aji, Joshua Whatley and Scott Ogden.

In Moto3 class, the vacancy left by Petronas SRT is occupied by the new VisionTrack Racing Team, which uses Honda bikes.

In the third session Enea Bastianini set the best time preceded by Pol Espargaró and Francesco Bagnaia.

In the combined time classification, reigning world champion Fabio Quartararo does not rank in the top ten and is forced to unpack Q1.