The 2021 Valencian Community motorcycle Grand Prix (officially known as the Gran Premio Motul de la Comunitat Valenciana) was the eighteenth and final round of the 2021 Grand Prix motorcycle racing season.

It was also the final Grand Prix for Valentino Rossi who retired after the season.

In the MotoGP class, Ducati Lenovo Team secured the Teams' Championship, its first since 2007 by making possible the first podium lock-up for Ducati in the MotoGP history with Francesco Bagnaia winning the race ahead of fellow Ducati riders Jorge Martín, who later became Rookie of the Year, and Jack Miller.

[2] Remy and his father Wayne became the second father-son World Champions after Kenny Roberts and Kenny Roberts Jr.[3] In the Moto3 class, KTM secured its fifth Constructors' Championship and its first since 2016.

[4] The race, scheduled to be run for 25 laps, was red-flagged due to a first-lap accident involving multiple riders and the resulting oil spill.