The 2022 Ronde van Drenthe was a Dutch road cycling one-day race that took place on 12 March 2022.

[2] Three Women's WorldTeams, EF Education–Tibco–SVB, Roland Cogeas Edelweiss Squad and Team Movistar skipped this race.

UCI Women's WorldTeams UCI Women's Continental Teams National Teams The 156 kilometres (97 mi) route from Assen to Hoogeveen uses generally flat roads in the Drenthe region of the Netherlands, with the challenge being four ascents of the VAMberg - a hill built on a landfill site.

The distance from the last ascent of the climb to the finish in Hoogeveen was 14 km, with a four woman group caught within the final kilometre.

Lorena Wiebes of Team DSM outsprinted world champion Elisa Balsamo to win in a bunch sprint, despite a suffering puncture in the closing stages of the race.