The 2022 Western Kentucky Hilltoppers football team represented Western Kentucky University as a member of Conference USA (C-USA) during the 2022 NCAA Division I FBS football season.

[1] Through the first two games, Reed had 550 passing yards, ranking third in the nation.

[2] The Conference USA media day was held on July 27 at Globe Life Field in Arlington, Texas.

[3] The Hilltoppers were predicted to finish third in the conference's preseason poll.

[4] Roster Last update: August 23, 2022 Western Kentucky and Conference USA announced the 2022 football schedule on March 30, 2022.