The 2023–24 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2023–24 NCAA Division I women's basketball season.

The team was led by 20th-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of the Sun Belt Conference.

The Lady Eagles finished as co-conference champions for the 2022–23 basketball season with an overall record of 21–10 and 13–5 in Sun Belt play to finish in a three-way tie for first place.

They lost in the conference tournament to Texas State 85–57[1] and were unable to secure a bid into the NCAA tournament.

Despite her recurring battle with lung cancer, head coach Joye Lee-McNelis stated that she would be back to coach the 2023–24 season.