The Cardinals matched their 4–13 record from the previous year after an upset win over the Philadelphia Eagles in Week 17.

After another loss to the Los Angeles Rams the next week,[3] they suffered their second consecutive double digit losing season.

After losing to the San Francisco 49ers in Week 15, the Cardinals were eliminated from playoff contention for the second consecutive season.

[5] On February 14, two days after Super Bowl LVII concluded, the Cardinals hired former Philadelphia Eagles' defensive coordinator Jonathan Gannon as the team's new head coach.

Tenth year general manager Steve Keim stepped down on January 9,[5] following a tenure that had included the drafting of Pro Bowlers D. J. Humphries and Kyler Murray, and All-Pros Haason Reddick and Budda Baker.

On January 16 the Cardinals hired former Tennessee Titans director of player personnel Monti Ossenfort as their new general manager.

The home uniform's numbers are accented with a silver outline and forgoes a sleeve pattern included on the alternate and away jerseys.

After taking a 21-point lead late in the third quarter, the Cardinals collapsed and allowed New York to score 24 unanswered points and win the game.

This game marked the return of quarterback Kyler Murray, who had been out since tearing his ACL on December 12, 2022 against the New England Patriots.