The 2023 season was the San Francisco 49ers' 74th in the National Football League (NFL), their 78th overall, their tenth playing their home games at Levi's Stadium and their seventh under the head coach/general manager tandem of Kyle Shanahan and John Lynch.

This was the team's first season since 2013 and 2016, respectively, without safety Jimmie Ward and quarterback Jimmy Garoppolo on the roster; Garoppolo signed with the Las Vegas Raiders on March 17, while Ward signed with the Houston Texans the following day.

Following the bye, the 49ers won 6 games in a row and, with a week 14 win over their NFC West rival, the Seattle Seahawks,[5] coupled with the Green Bay Packers' loss to the New York Giants on Monday Night Football,[6] became the first team to clinch a playoff berth in 2023,[7] their fourth in five seasons.

The following week the 49ers clinched the NFC West in consecutive seasons for the first time since 2011–2012 with a 45–29 win over the Arizona Cardinals.

[8] With a 27–10 Week 17 win over the Washington Commanders, and the Detroit Lions and Philadelphia Eagles losing, the 49ers clinched home-field advantage throughout the NFC playoffs for the first time since 2019.

Despite clinching the number one seed, the team failed to match their 13–4 record from the previous year, going 12–5.

[11] They also established an NFL record by becoming the first team in league history to have four players with over 1,000 scrimmage yards, with Deebo Samuel (1,085), George Kittle (1,022), Christian McCaffrey (2,023) and Brandon Aiyuk (1,317) all surpassing the mark.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.