[1] The Eagles failed to equal or improve on their 14–3 record from the previous year due to their loss to the Seattle Seahawks in Week 15.

The Eagles also notably lost the NFC East division title and second seed to the Dallas Cowboys in Week 18 after the latter's blowout victory against the Washington Commanders, and their own loss to the Giants.

The Eagles' late-season woes continued into the playoffs, in which they were eliminated in the Wild Card round by the NFC South champion Tampa Bay Buccaneers in a 32–9 blowout loss.

New England would rally back with a pair of TD passes from Mac Jones to Hunter Henry and Kendrick Bourne.

[24] This win, along with a Miami Dolphins loss to the Buffalo Bills, allowed Philadelphia to become one of only two unbeaten teams remaining, the other being the San Francisco 49ers, who defeated the Arizona Cardinals later that day.

The Eagles entered their Week 6 matchup with the New York Jets as the lone remaining undefeated team in the league, thanks to the San Francisco 49ers' loss to the Cleveland Browns just moments after the kickoff.

With their lead down to 14–12 at the two-minute warning, Jalen Hurts was picked off by Tony Adams, and gave the Jets an opportunity to win the game.

Breece Hall scored the go-ahead touchdown for New York on the very next play, and Philadelphia failed to respond on their final drive, allowing the Jets to run the clock out.

Following their first-ever loss to the New York Jets, the Eagles returned to Lincoln Financial Field to face the AFC East-leading Miami Dolphins.

After trading field goals with the Dolphins in the first quarter, the Eagles would jump out to a 17–3 lead on a Dallas Goedert touchdown reception, followed by a Jalen Hurts quarterback sneak.

The teams traded punts to start the second half, before the Eagles forced a turnover on downs on a controversial play where James Bradberry appeared to grab the face mask of Cedrick Wilson Jr., but no penalty was called.

With the 31–17 win, the Eagles improved to 6–1 on the season, and became the top team in the conference when the San Francisco 49ers lost to the Minnesota Vikings the following night.

Despite committing multiple mistakes in the game's closing minutes, the Eagles staved off a late Cowboys rally to preserve a 28–23 win.

The Eagles narrowly escaped with the victory when Dak Prescott completed a pass to CeeDee Lamb, who was tackled by Darius Slay four yards short of the end zone as time expired.

In the fourth quarter, the Chiefs converted a 4th-and-1 in the Eagles red zone, but on the next play, Bradley Roby stripped the ball from Kelce and Nicholas Morrow recovered the fumble.

Mahomes' pass to Watson fell incomplete, turning the ball over on downs, and allowing the Eagles to run out the clock.

While the Bills took the lead just after the two minute warning with another touchdown, Jake Elliott converted a 59 yard field goal with 20 seconds left to force overtime.

While Philadelphia did respond in the second half with a fumble recovery touchdown by Jalen Carter, the Eagles could not score again, while Aubrey converted 3 more field goals.

New York responded with a two-play 75-yard drive, culminating in Darius Slayton scoring on a 69-yard pass from Tyrod Taylor, cutting the Eagles' lead to 30–25.

The Giants, now needing a touchdown and a two-point conversion to send the game into overtime, drove to the Philadelphia 26-yard line with three seconds remaining, but Taylor threw a pass that was intercepted in the end zone by Eagles cornerback Kelee Ringo, sealing the victory for the Eagles and snapping their three-game losing streak.

[38] The Eagles improved to 11-4 with the win and regained control of the NFC East following the Dallas Cowboys' loss to the Miami Dolphins the previous night.

In the fourth quarter, Philadelphia and Arizona each scored touchdowns, from Dallas Goedert and Michael Wilson respectively, keeping the game tied at 28–28.

Despite the Cardinals attempting an onside kick and failing to recover, a poor offense led Philadelphia to do a field goal to take the lead with two minutes left in regulation, during which key receiver DeVonta Smith was injured and withdrew from the game.

With 32 seconds left to play, Jalen Hurts attempted a last-ditch effort to score only to be intercepted by Joey Blount, mirroring Philadelphia's defeat to the Seattle Seahawks two weeks prior, thus sealing the upset for Arizona.

Although New York's offense had cooled down by then, the Eagles were unable to overcome the deficit as they ended the regular season with a 27–10 loss.

Philadelphia returned to the playoffs coming off a disastrous late-season collapse that saw them fall into the fifth seed, and were hoping to reverse their momentum with a win over NFC South champion Tampa Bay.

Brown, who suffered a knee injury in the regular season finale against the New York Giants, was unable to make it to the game.

Most notably, cornerback James Bradberry made contact with Trey Palmer but failed to bring him down, proving costly as it facilitated his 56-yard touchdown run in the third quarter.

Following their touchdown, Philadelphia attempted a "tush push" maneuver for a two-point conversion, but Tampa Bay was able to hold them off and pull Hurts away from the end zone.