The race was won by Belgian rider Lotte Kopecky of SD Worx for the second year running, after a solo attack with around 20 kilometres remaining.

[2] In the run up to the event, SD Worx had won Ronde van Drenthe, Gent–Wevelgem and Dwars door Vlaanderen - and therefore teammates Demi Vollering, Marlen Reusser and Lotte Kopecky were considered favourites.

Annemiek van Vleuten crashed, ending the possibility of a third Tour of Flanders win at her final attempt at the race.

[1] The break was caught at the bottom of the Koppenberg climb, with only Reusser and Silvia Persico of UAE Team ADQ able to complete the cycle to the top.

A chase group behind of van Anrooij, Persico, Niewiadoma and Vollering realised that they could not catch Kopecky, and Reusser, Labous and Longo Borghini joined them.