The 2024–25 EHF Champions League knockout stage will begin on 26 March with the playoffs and end on 15 June 2025 with the final at the Lanxess Arena in Cologne, Germany, to decide the winners of the 2024–25 EHF Champions League.
A total of twelve teams will compete in the knockout phase.
In the playoffs, the eight teams ranked 2nd–6th in Groups A and B play against each other in two-legged home-and-away matches.
The four quarterfinal winners qualify for the final four tournament at the Lanxess Arena in Cologne, Germany.
The final four will held at the Lanxess Arena in Cologne, Germany on 14 and 15 June 2024.