The 2024–25 season is the 105th season in the history of US Sassuolo Calcio, and the club's first season in Serie B since 2013, following relegation from the top flight in the previous campaign.

In addition to the domestic league, the club is participating in the Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Last updated: 24 September 2024 Source: [ Soccerway] Source: [citation needed] The match schedule was released on 10 July 2024.