The Cardinals improved on their 4–13 record from the previous 2 seasons following a Week 9 victory against the Chicago Bears.

However, they suffered their fourth late season collapse in five years and were eliminated from playoff contention for the third consecutive season after an overtime loss to the Carolina Panthers coupled with the Los Angeles Rams beating the New York Jets in Week 16.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

The Cardinals won by 31 points, their largest margin of victory since 2016, when they secured a 44–6 win also against the Rams.

Quarterback Kyler Murray posted a perfect passer rating completing 17 of 21 passes for 266 yards and 3 touchdowns.