After a win against the Minnesota Vikings in the final game of the regular season, the Lions won their second consecutive division title and clinched the No.
They swept the NFC North for the first time, which was the best single-season division in NFL history by combined winning percentage.
The Lions opened the regular season at home against the Los Angeles Rams, in a rematch of the 2023 NFC Wild Card game.
The Rams scored ten points in the fourth quarter via a 26-yard field goal by Karty and a nine-yard touchdown pass from Matthew Stafford to Cooper Kupp, to regain the lead.
In week 2, the Lions hosted the Tampa Bay Buccaneers, in a rematch of the 2023 NFC Divisional Round game.
The Buccaneers regained the lead via a 41-yard touchdown pass from Baker Mayfield to Chris Godwin, which made the score 13–6 in favor of Tampa Bay at half-time.
The Lions scored ten points in the third quarter via a 32-yard field goal by Bates and a one-yard touchdown run from David Montgomery to take their first lead of the game.
In a scoreless fourth quarter, the Lions' attempted comeback failed after turning the ball over on downs after three consecutive incomplete passes by Jared Goff, making the final score 20–16 in favor of Tampa Bay.
The Cardinals responded with a ten-yard touchdown pass from Kyler Murray to Marvin Harrison Jr. to tie the game.
The Lions scored 14 points in the second quarter via two rushing touchdowns by Jahmyr Gibbs from three-yards, and one-yard, respectively.
The Seahawks responded with a one-yard touchdown run from Kenneth Walker III, which made the score 21–7 in favor of Detroit at half-time.
This was the Lions' first win over the Cowboys since 2013, snapping a six-game losing streak; however, the victory was marred when Aidan Hutchinson suffered a broken tibia and fibula in the third quarter.
Originally thought to be season-ending, Lions head coach Dan Campbell said that Hutchinson would need "4 to 6 months" to recover.
The Vikings scored ten points in the first quarter via a 34-yard touchdown run from Aaron Jones and a 57-yard field goal by Will Reichard.
The Vikings scored 12 points in the fourth quarter via two field goals by Reichard, from 42-yards, and 48-yards, respectively, and a 36-yard fumble return by Ivan Pace Jr., to regain the lead.
The Vikings, however, failed a two-point conversion following their defensive touchdown, which gave the Lions an opportunity to retake the lead with field goal, and did so a 44-yarder by Jake Bates with 15 seconds remaining in the game, making the final score 31–29 in favor of Detroit.
The Titans tied the game in second quarter via a five-yard touchdown pass from Rudolph to Nick Westbrook-Ikhine.
The Lions scored 17 points in the second quarter via a three-yard touchdown pass from Jared Goff to Amon-Ra St. Brown, a 27-yard field goal by Jake Bates, and a 27-yard interception return by Kerby Joseph, which made the score 17–3 in favor of Detroit at half-time.
The Texans scored ten points in the first quarter via an eight-yard touchdown run from Joe Mixon and a 34-yard field goal by Kaʻimi Fairbairn.
The Texans responded with 13 points in the quarter via two field goals by Fairbairn, from 56-yards, and 29-yards, respectively, and a 15-yard touchdown pass from C. J. Stroud to John Metchie III, which made the score 23–7 in favor of Houston at half-time.
The Lions scored 13 points in the fourth quarter via a nine-yard touchdown pass from Goff to Amon-Ra St. Brown, and two field goals by Jake Bates, from 58-yards, and 52-yards respectively.
The Lions became the first team to win when throwing five or more interceptions in a game since Matt Ryan of the Atlanta Falcons defeated the Arizona Cardinals on November 18, 2012.
[83] The Lions also became the first team since the 1970 Baltimore Colts to win after overcoming a deficit of at least 15 points while throwing five or more interceptions.
[85] The Lions scored touchdowns on their first seven possessions of the game, the first NFL team to accomplish this feat since the 2007 New England Patriots.
With the clock running out, Williams threw a desperation pass towards the end zone to Rome Odunze, which was incomplete, allowing the Lions to hold on for a 23–20 win.
These injuries added to Detroit's existing defensive challenges, with several key players already on injured reserve, including Pro Bowler edge rusher Aidan Hutchinson and linebacker Alex Anzalone.
The Bills scored 13 points in the fourth quarter via a five-yard touchdown pass from Allen to Ray Davis, and two field goals by Bass, from 50-yards, and 41-yards, respectively.
The Lions scored the final ten points of the quarter via a 57-yard field goal by Jake Bates and a four-yard touchdown pass from Goff to Amon-Ra St. Brown, to take their first lead of the game.
The Lions scored nine points in the fourth quarter via a 42-yard field goal by Bates and a 30-yard touchdown run from Jahmyr Gibbs.
Despite the Commanders missing a 44-yard field goal on their ensuing possession, the Lions' loss was sealed after Goff threw his third interception with under 30 seconds left in the game.