It was their eighth under the leadership of general manager Chris Ballard and the second under head coach Shane Steichen.

They failed to improve on their 9–8 record from last year and end their nine-year AFC South title drought after a Week 15 blowout loss to the Denver Broncos.

They were eliminated from playoff contention following a Week 17 upset loss to the New York Giants, who before the game had the worst record in the league.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Colts' preseason opponents and preliminary schedule were announced on May 15, in conjunction with the release of the regular season schedule.

After a decent first half in which the Colts led by six points, intercepting Bo Nix thrice, the Broncos controlled the rest of the game.

The Colts had five turnovers in the second half, including Jonathan Taylor prematurely celebrating a touchdown by dropping the ball before scoring, leading to a touchback, and a failed trick play resulting in a Broncos touchdown by Nik Bonitto.

With the loss, the Colts fell to 6–8 and allowed the Texans, who won earlier that day, to clinch the AFC South division title.

With the upset loss, the Colts fell to 7–9 and became eliminated from playoff contention.