After kicker Graham Gano suffered an injury on the opening kickoff, the Giants became the first team to lose a game in regulation in which they scored three touchdowns and allowed none.

Head coach Brian Daboll was heavily criticized for not signing a second kicker and undermanning the Giants for being unable to kick extra points and field goals that could have changed the outcome of the game.

Eric Gray fumbled the opening kickoff, and Deshaun Watson found Amari Cooper on the first play from scrimmage to give the Browns a 7–0 lead 11 seconds into the game.

In the second quarter, Malik Nabers took over, snatching a deep ball from a defender, then capped the drive off with an acrobatic touchdown catch to give the Giants a 14–7 lead.

Nabers scored his second touchdown of the quarter 4 plays later, and the Giants went into the locker room with a 21–7 halftime lead to a stunned Browns crowd.

On the Cowboys first touchdown of the game, the referees picked up a holding penalty on tight end Jake Ferguson despite him grabbing a Giants defender, paving the lane for Rico Dowdle to score.

Running back Eric Gray got the starting nod and had 3 receptions on the opening drive, but fumbled on 4th-and-goal, which Seahawks safety Rayshawn Jenkins recovered in the end zone and returned it untouched for a 101-yard touchdown for Seattle.

On the Seahawks opening drive of the third quarter, Deonte Banks stripped DK Metcalf in field goal range, and Jones immediately responded with two deep balls to Darius Slayton, the latter a 30-yard touchdown to take a 17–10 lead.

The Seahawks found rhythm on a late fourth quarter drive capped off with a Jaxon Smith-Njigba touchdown and then forced a three-and-out to get the ball back with 1:40 to play.

On the field goal attempt, Isaiah Simmons jumped over the A-gap without making contact with the long snapper, blocked the kick, and wide receiver Bryce Ford-Wheaton recovered the ball and ran untouched for a Giants touchdown, sealing the 29–20 victory.

Despite a defensive battle through the first quarter and a half, with the first seven drives combined between both teams ending in punts, Barkley broke through with a 55-yard run to put the Eagles in the red zone.

Coincidentally, their last home win happened against the Eagles in Week 18 the prior season, which was Barkley's final game as a Giant.

In a penalty-ridden game for both teams, touchdowns were hard to come by until the third quarter, when Calvin Austin returned a punt 73 yards to the house for the Steelers.

Daniel Jones turned the ball over in the red zone twice and got sacked on a flea-flicker play in which he had two wide-open receivers, in what proved to be his final start as a Giant.

Although the Giants won the coin toss, Tyrone Tracy Jr. fumbled on the first play from scrimmage, giving the Panthers the ball in field goal range.

Tommy DeVito made his first start of the season, but the Giants couldn't get anything going on offense until garbage time in the fourth quarter, when Devin Singletary managed to score his first touchdown since Week 3.

The Giants defense went their tenth consecutive game without recording an interception, having not gotten one since rookie linebacker Darius Muasau did during their Week 1 loss to the Vikings.

During the Giants opening drive, Drew Lock managed to escape the pocket during a blitz on 3rd-and-6 from the Dallas 29-yard line, breaking free and appearing to run all the way to the end zone for a touchdown.

In the fourth quarter down 27–13, the Giants managed to put together a much-needed touchdown drive, with Drew Lock scoring on an 8-yard run, pulling the game to 27–20.

After the loss, it was revealed that both Theo Johnson and Dexter Lawrence would miss the remainder of the season, suffering a Lisfranc foot injury and dislocated left elbow respectively.

On the ensuing two-point conversion attempt, Malik Nabers was able to catch a tipped pass from Drew Lock and cross the plane, bringing the score to 14–11.

The Giants had a chance to score a field goal and tie the game to force overtime on their final drive, but Graham Gano's attempt was blocked, sealing their eighth straight loss (the team's longest losing streak since 2019), and falling to 2–11.

During the loss, the Giants recorded their first defensive interception since week 1, courtesy of cornerback Tre Hawkins III, although it was later announced that he had suffered a season-ending back injury in this game.

After the two teams exchanged punts, Baltimore marched down the field, with tight end Mark Andrews scoring a touchdown to give the Ravens the lead.

In the fourth quarter, on another penalty-ridden drive for the Baltimore defense, Tim Boyle connected with Malik Nabers on a 4th-and-3 from the 23-yard line to score the second Giants touchdown of the day, although the game was well out of reach at that point.

Just like he did in the Thanksgiving game, Lock followed the touchdown drive by throwing a pick-six on the very next possession, this time to Jessie Bates, giving Atlanta the lead for good.

The lone bright spot was Malik Nabers breaking the record of 91 receptions for a Giants rookie shared by Odell Beckham Jr. and Saquon Barkley, finishing the game with 97 on the season.

After both teams traded numerous touchdown drives in the second half, rookie cornerback Dru Phillips sealed the game with his first career interception late in the fourth quarter.

The Giants also got swept by every team in their division for the first time in franchise history and additionally suffered their 12th straight road loss to Philadelphia.

The next day, amid speculation that either one or both of them could be fired, owner John Mara announced that both Daboll and General Manager Joe Schoen would be retained for the following season.