The 22nd Indiana Volunteer Infantry Regiment was an infantry regiment that served in the Union Army during the American Civil War.

On October 8, 1862, at the Battle of Perryville, Kentucky, the regiment suffered 65.3% casualties, one of the highest percentages of casualties suffered by any American Civil War regiment in a single engagement.

[1] Attached to Army of the West and Department of Missouri September 1861 to January 1862.

30th Brigade, 9th Division, Army of the Ohio, September 1862.

30th Brigade, 9th Division, III Corps, Army of the Ohio, to November 1862.

1st Brigade, 1st Division, Right Wing, XIV Corps, Army of the Cumberland, to January 1863.

1st Brigade, 1st Division, XX Corps, Army of the Cumberland, to October 1863.

2nd Brigade, 1st Division, IV Corps, Army of the Cumberland, October 1863.

March to relief of Colonel Mulligan at Lexington, Missouri, September.

Action at Milford (or Shawnee) Mound on Blackwater Creek and capture of 1,300 prisoners on December 18.

Moved to Cape Girardeau, Missouri, thence to Corinth, Mississippi, May 20–28.

Duty at Jacinto and other points in Northern Mississippi till August 17.

Passage of the Cumberland Mountains and Tennessee River and Chickamauga, Georgia, Campaign August 16-September 22.

Guard supply trains over Mountains in rear of Bragg's army during Battle of Chickamauga.

Operations on line of Pumpkin Vine Creek and battles about Dallas, New Hope Church and Allatoona Hills May 25-June 5.

Taylor's Hole Creek, Battle of Averasborough, North Carolina, March 16.

Moved to Louisville, Kentucky, June and duty there till July.

[2] The regiment lost 14 officers and 139 enlisted men killed in action or died of wounds and 190 enlisted men who died of disease, for a total of 343 fatalities.