It begins as 22nd Street East in the Central Business District.

From there is passes by the neighbourhoods of Pacific Heights, Blairmore, and Kensington.

[1] Prior to 2005, 22nd Street used to turn southwest near the present-day Hart Road intersection and continue as Highway 7, while traffic had to leave the roadway to follow Highway 14.

[2] The roadway was removed to make way Blairmore Suburban Centre, with 22nd Street transitioning directly to Highway 14, while Highway 7 temporarily followed Betts Avenue from 2005-2012 and then was moved to its permanent realignment via Nault Road.

[citation needed] For the portion of Saskatoon west of the South Saskatchewan River, 22nd Street serves as the dividing line between "North" and "South" addresses.