Transferred to the Wise Legion on July 10 with the consent of Col. Charles Q. Tompkins, they became Company F of the 46th Virginia Infantry and in August 1861 were transferred again and became Company E of the 60th Virginia Infantry[6] The Kanawha Artillery (also referred to as Hale's Battery) was organized in Charleston by Dr. John Peter Hale, who also financed it at the suggestion of then-Col. John McCausland.

It was assigned to Echols' and Patton's Brigade, participated in the Shenandoah Valley operations, and disbanded during the spring of 1865.

As the Civil War began in western Virginia the 22nd was known as the 1st Kanawha Riflemen upon entering into service of the Confederacy in June 1861.

Captain George Patton won a major victory for the Confederates, and he was wounded in the shoulder, he was left at Charleston, West Virginia.

The infighting between Wise and John B. Floyd (also a former Governor of Virginia himself who had been sent to the Kanawha Valley) and the disorder of the Confederate forces caused President Jefferson Davis to send General Robert E. Lee to the region to supervise.

Following the unsuccessful attack to take Cheat Mountain to the north, Lee moved south to take command of the Army of the Kanawha Valley District after Floyd's defeat at Carnifex Ferry on September 10, 1861.

Prior to Carnifex Ferry, Floyd sent a dispatch to General Wise stating he needed support in order to keep his position.

General Wise denied the arrival of part of his army until another dispatch came, this time begging for support.

In September, the regiment fought in Major General William W. Loring's Kanawha Valley Campaign of 1862 as part of a brigade commanded by Brigadier General John S. Williams or detached to a brigade commanded by Colonel Gabriel C. Wharton.

These books contained information on the Virginia Supreme Court of Appeals for the convenience of lawyers and judges.

At dawn the Union Army under the command of General Averell, sent out skirmishers to test the Confederate line.

Echols was aware of the situation even though the center and the right were heavily engaged, and ordered the left flank to be reinforced.

Seeing the Confederate right and center falling back, Echols sent three companies of the 22nd Virginia to support the left flank.

As the order of retreat was called to the Confederates, Colonel Jackson held the center for another half hour until the artillery was removed from the field.

Even though the battle of Droop Mountain was a Confederate defeat, Echols managed to survive from the main thrust of the Union Army and prevented Averell from completing their raid on the Virginia and Tennessee Railroad.

In 1864 the 22nd Virginia was transferred to General John C. Breckinridge to protect the Shenandoah Valley from the invading Federals.

They also went into the Shenandoah Valley to relieve some of the pressure off of General Lee's lines and force Grant to send troops away from Petersburg.

General Jubal Early then traveled up the Shenandoah Valley and entered Maryland at Shepherdstown, West Virginia.

On July 8 at Turners Gap, near Middletown MD, the 22nd Virginia engaged in a series of skirmishes that finally ended at Frederick, Maryland in the late evening.

Once Early entered the Shenandoah Valley, the 22nd Virginia participated in the battles of Cool Springs, Kernstown, and Winchester.