After completing its organization, the regiment moved to Vienna and drilled there for the next few months before being encamped near Milliken's Bend.

[2] Sent to south Louisiana in November to join General Richard Taylor's command, the 28th encamped at Avery Island for a brief period before relocating to Fort Bisland.

The regiment then retreated to Natchitoches with Taylor's army, returning to south Louisiana in June.

[2] When the Red River Campaign commenced in mid-March, the brigade crossed to Alexandria and retreated towards Natchitoches once again.

It camped on Bayou Cotile May 1865, when the regiment marched to Mansfield and disbanded there on 19 May, just before Taylor surrendered his command.