The 2nd Avenue Lofts is a historic building located in the Central Business District of Saskatoon, Saskatchewan, Canada.

J. F. Cairns settled in Saskatoon in 1902, opening the first mill in the city before entering the retail business.

[2] In 2000, HBC left the building to move into the former Eaton's location in Midtown Plaza (Saskatoon) shopping centre a few blocks away.

[2] A fifth story was added to the building, and due to the high ceiling on each floor it was possible to create each loft with an internal mezzanine.

[5] The conversion from retail to lofts is part of a larger residential revival occurring in the central business district with an influx of people moving into the area.