After joining an all-Louisiana brigade, it fought at Cedar Mountain, Second Bull Run, Antietam, and Fredericksburg in 1862, at Chancellorsville, Second Winchester, Gettysburg, and Mine Run in 1863, and at the Wilderness, Spotsylvania, Cold Harbor, Monocacy, Third Winchester, Fisher's Hill, Cedar Creek, and Petersburg in 1864, and at Appomattox in 1865.

[2] After an artillery barrage, four companies of the 3rd Vermont Infantry waded across a pond and captured a line of Confederate rifle pits.

After 40 minutes, they were counterattacked by a brigade of Georgians and Louisianians and driven off with 83 casualties out of the 192 Vermonters who carried out the probe.

[4] At the Battle of Malvern Hill on 1 July 1862, the troops led by Major General John B. Magruder carried out uncoordinated attacks instead of one concentrated assault.

In Cobb's brigade, the 2nd Louisiana Infantry suffered 182 killed, wounded, and missing, the second highest losses of any Confederate regiment.

[6] Colonel Leroy Augustus Stafford of the 9th Louisiana assumed command of the brigade, which suffered losses of 110 killed, 269 wounded, and 6 missing during the battle.

[2] At the Battle of Antietam on 17 September 1862, Starke's brigade counted about 650 men and sustained losses of 70 killed and 204 wounded.

[11] The regiment took part in Lieutenant General Thomas J. Jackson's flank attack on 2 May and in the bitter fighting on 3 May.

[15] On 15 June at the Second Battle of Winchester, the 2nd and 10th Louisiana Infantry captured approximately 1,000 Union soldiers.

[12] The brigade was led by Brigadier General Stafford and was part of Johnson's division and Ewell's Second Corps.

[18] By 1864, Stafford's Louisiana brigade had won a reputation for drinking, pillaging, and hard fighting according to historian Gordon C.

[19] From 1 to 3 pm on 5 May, Stafford's brigade helped repulse Union V Corps attacks at Saunders' Field.

The other Louisiana brigade under Brigadier General Harry T. Hays' rushed from the reserve to fill the gap, but lost one-third of its numbers in the fighting.

[17] An assault at first light on 12 May by the Union II Corps overran Johnson's division at the Bloody Angle, capturing 2,800 men and 20 artillery pieces.

The initial Union success was followed by brutal fighting that lasted all day, with neither side winning any advantage.

[2] On 13 June, because Union soldiers were threatening Lynchburg, the Second Corps under Major General Jubal Early began moving to the Shenandoah Valley.

[24] The regiment fought in the Valley campaigns of 1864 in the summer and fall, serving at the battles of Monocacy, Third Winchester, Fisher's Hill, and Cedar Creek.