On the 7th of December the Second Cavalry left Davenport for Benton Barracks near Saint Louis.

While here the men were crowded into closed quarters where a great amount of sickness prevailed resulting in sixty deaths.

Among other engagements, the Regiment took part in Grierson's Raid through Mississippi in April 1863, being detached from the main column (6th and 7th Illinois Cavalry) after a few days to decoy the Confederate pursuit.

They engaged the 2nd/22nd Tennessee Cavalry (Barteau's) at Palo Alto, Mississippi on April 21 and 22, 1863 and reported six missing after the skirmish.

This article about a specific military unit of the American Civil War is a stub.