[1] DMB inhibits microbial trimethylamine (TMA) formation in mice and in human feces, thereby reducing plasma trimethylamine N-oxide (TMAO) levels after choline or carnitine supplementation.

[1] It consequently inhibited choline-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in mice without alterations in circulating cholesterol levels.

[1] While mice placed on a choline supplemented diet showed an increase in the proportions of the bacterial taxon Clostridiales in the gut, DMB induced a decrease in the proportions of this taxon.

[1] Mice showed no evidence of toxicity to chronic (16-week) DMB exposure.

[1][2] DMB is found in some balsamic vinegars, red wines, and some cold-pressed extra virgin olive oils and grape seed oils.