300 Main (informally known as the Artis REIT Residential Tower) is a multi-family residential high-rise building on Main Street in Winnipeg, Manitoba, Canada.

[3] Standing at 141.7 metres and 42 storeys, it is the tallest building in Winnipeg as well as in Manitoba.

[6] On its first floor is an Earls restaurant, which was previously located two blocks south, closer to The Forks.

[6] It is the first residential building to be located at the 300 block near Portage and Main.

[8] In March 2021, it reached the height of 128 metres (420 ft), passing 201 Portage, which had been Winnipeg's tallest tower since 1990.