Peter, Brian, Cleveland and Joe are annoyed when Quagmire adopts a stray cat named James and prefers to spend more time with him than with them.
He attempts to use Stewie's urine when Joe arrives to perform a drug test, only to be caught by Lois, who chastises him for going to such lengths and tells him that he has to change if he intends on doing so.
Mayor West passes a law to legalize the drug, and everyone (except for Lois, her father Carter, and the kids) starts smoking it; the town has improved as a result, with milestones such as an increase in productivity and a decrease in crime.
However, Carter begins to lose money in the timber industry since hemp is being used to manufacture many products, particularly paper, and he bribes Peter to help him with an anti-marijuana campaign.
[10] One cutaway sees Peter stating he gets excited when the title of a film is said within the film, with such examples including Clear and Present Danger, As Good as It Gets, and Superman IV: The Quest for Peace; this joke returns during Brian's arrest for marijuana possession; as one police officer is arresting Brian, he states that he doesn't tolerate drug users since he is a "family guy", to Peter's amusement.
[10][11] Peter then tries to set up a cutaway joke but can't due to being high, and ends up listing the names of celebrities whom he does not like in a text crawl.
[10][11] He then says Neil Patrick Harris was cast on How I Met Your Mother based on his work in that film, and brings up a point that confuses him: since Josh Radnor is already an adult, why is the narrator of the show voiced by Bob Saget?
[14] The TV Critic's Robin Pierson gave the episode a 54/100; in his review, he appreciated the plot structure, especially the randomness of Peter's list of hated cultural icons.
He did, however, criticize the featured musical number; he referred to it as a "waste of time" and claimed that "jokes about Texans, Michael Jackson, and Helen Keller are so obvious.
"[15] The Parents Television Council, a frequent critic of Family Guy and series creator Seth MacFarlane, branded a June 6, 2009 re-airing their "Worst TV Show of the Week", due to its emphasis on the legality of cannabis.
[16] The Venezuelan government reacted negatively to the episode and banned Family Guy from airing on their local networks, which generally syndicate American programming.
Justice Minister Tareck El Aissami stated that any cable stations which refuse to stop airing the series would be fined and he also claimed that it promoted the use of cannabis.