The 46th Battalion (South Saskatchewan), CEF, was an infantry battalion of the Canadian Expeditionary Force during the Great War.

The 46th Battalion was authorized on 7 November 1914 and embarked for Britain on 23 October 1915.

On 11 August 1916 it disembarked in France, where it fought with the 10th Infantry Brigade, 4th Canadian Division in France and Flanders until the end of the war.

The 46th Battalion lost 1,433 killed and 3,484 wounded – a casualty rate of 91.5 percent in 27 months.

Sergeant Hugh Cairns was posthumously awarded the Victoria Cross for his actions at Valenciennes on 1 November 1918.