The series is set in the Punjabi Market district of Vancouver, British Columbia.
Much like ITV's Coronation Street, 49th & Main focuses on the interactions of the businesspeople, merchants and residents of the multicultural area.
In particular, the series revolves around Dr. Cedric Ferreira, a Kenyan-born Indian with an English upbringing, who decides to bring his young son to Canada and start a medical practice.
The cast of 49th & Main includes Cedric de Souza (in the role of Dr. Ferreira), as well as Rekha Sharma, Agam Darshi, Brandon Jay McLaren, Balinder Johal and William B. Davis.
The six episodes were taped in Vancouver in March and April 2006, and an initial pilot was shot in early 2005.